Title: Chemical fingerprinting and in vitro toxicological profiling for the safety evaluation of transgenic food crops.
Subject:
compositional analysis genetic engineering transgenic food crops tomatoes potatoes biotechnology extractionTags (biotech)
Author/s: Noteborn, H.P.J.; Lommen, A.; Weseman, J.M.; Jagt, R.C.M. van der; Groenendijk, F.P.F.
PR-AM
1998
BIC49
SEARCA Library
Printed
Ministry of Economic Affairs,
January 1998
The Hague, The Netherlands :
The approach of chemical fingerprint analysis is at an early stage of development. But the methodology may be an important pat in evolving strategies for a tiered approach focusing on comparative analytical-chemical and toxicological analysis of novel foodstuffs. A dynamic, establishment of substantial equivalence that may yield better, more efficient, less costly tests or tests which utilise fewer laboratory animals. Methods which could be used in conjunction with the conventional determination of key nutrients and toxicants. Further validation of the method from the context of its application in prediction of critical changes is necessary. In addition, there is a need for data from multiple locations in order to enable the discrimination between unintended effects of insertional events (i,e, pleitropic effects) and those of environmental factors.
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